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KMID : 0356620110260020160
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Journal of Korean Society of Endocrinology
2011 Volume.26 No. 2 p.160 ~ p.165
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A Case of Pituitary Adenoma with Simultaneous Secretion of TSH and GH
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Lee Eun-Young
Ku Cheol-Ryong
Kim Hyun-Min
Lee Woo-Kyoung
Lim Jung-Soo
Hwang Se-Na
Kim Do-Hwan
Shin Dong-Yeob
Lee Eun-Jig
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Abstract
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Thyrotropin (TSH)-secreting pituitary adenoma is a very rare disease. In one-quarter of patients suffering from this disease, the pituitary tumor secretes other anterior pituitary hormones. Herein, we report a case of pituitary adenoma with simultaneous secretion of TSH and growth hormone (GH). A 34-year-old female visitied local hospital complaining of sweating, intermittent palpitation, and weight loss of 8 kg within 1 year. The patient had undergone trans-sphenoidal surgery 3 years prior for resolution of a TSH and GH co-secreting pituitary adenoma. She had been administered somatostatin analogue prior to visiting our hospital. The patient’s GH levels were suppressed to below 1 ng/mL on the 75 g oral glucose tolerance test, and her basal insulin-like growth factor-I (IGF-I) level was within normal range. Thyroid function tests demonstrated increased levels of both free thyroxine and TSH. Sella-MRI revealed pituitary adenoma at the floor of the pituitary fossa, approximately 2 cm in height. Therefore, she was diagnosed with residual TSH-secreting pituitary adenoma. The patient again underwent trans-sphenoidal surgery and entered complete remission, based on hormone levels and MRI findings.
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KEYWORD
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Thyrotropin, Growth hormone, Pituitary adenoma
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